| Chemical Properties | Back Directory | [Boiling point ]
739.8±70.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 12.5 mg/mL (28.57 mM) | [form ]
Solid | [pka]
3.75±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
S516 (Compound 22) is an active metabolite of CKD-516 and a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. S516 has marked antitumor activity[1]. | [in vivo]
S516 (Compound 22; 5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) in human LX-1 lung cancer and CX-1 colon cancer mouse xenografts[1]. | Animal Model: | Mice bearing 3LL lung cancer[1] | | Dosage: | 5 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Had promising antitumor activity (inhibition ratio (IR)> 63%). |
| [storage]
Store at -20°C | [References]
[1] Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54. DOI:10.1021/jm1002414 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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