| Chemical Properties | Back Directory | [Boiling point ]
557.2±50.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.57±0.40(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects[1]. | [References]
[1] Daouti S, et al. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res. 2008 Feb 15;68(4):1162-9. DOI:10.1158/0008-5472.CAN-07-2349 |
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MedChemExpress
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www.medchemexpress.com |
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