| Identification | Back Directory | [Name]
6-CHLORO-3-NITROQUINOLIN-4-OL
| [CAS]
101861-61-4 | [Synonyms]
6-CHLORO-3-NITROQUINOLIN-4-OL
6-chloro-3-nitro-4-Quinolinol
4-Quinolinol,6-chloro-3-nitro-
6-chloro-3-nitro-1H-quinolin-4-one | [Molecular Formula]
C9H5ClN2O3 | [MDL Number]
MFCD09800425 | [MOL File]
101861-61-4.mol | [Molecular Weight]
224.6 |
| Hazard Information | Back Directory | [Synthesis]
Step 2: Synthesis of 6-chloro-3-nitroquinolin-4-ol
To a 500 mL round bottom flask was added 5-chloro-2-(2-nitroethylideneamino)benzoic acid (25 g, 0.10 mol), K2CO3 (42.6 g, 0.30 mol) and acetic anhydride (250 mL). The reaction mixture was heated to 90 °C and the reaction was stirred at this temperature for 1 hour. Upon completion of the reaction, the resulting solid product was collected by filtration, washed sufficiently with deionized water to remove residual reactants and salts, and subsequently dried to afford 17.5 g (76% yield) of 6-chloro-3-nitroquinolin-4-ol as a gray solid. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 9.12 (s, 1H), 8.15 (s, 1H), 7.72 (s, 2H). Mass spectral analysis showed m/z: 224 (M+H+). | [References]
[1] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 93
[2] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 199-200 |
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