| Identification | Back Directory | [Name]
L-Arginine, N2-[[3-[(2,1,3-benzothiadiazol-4-ylsulfonyl)aMino]-2-thienyl]carbonyl]- | [CAS]
1018927-63-3 | [Synonyms]
EG00229 >=98% (HPLC)
ZWWMEDURALZMEV-NSHDSACASA-N
EG00229 free base
(EG 00229
N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine
L-Arginine, N2-[[3-[(2,1,3-benzothiadiazol-4-ylsulfonyl)aMino]-2-thienyl]carbonyl]- | [Molecular Formula]
C17H19N7O5S3 | [MDL Number]
MFCD18251520 | [MOL File]
1018927-63-3.mol | [Molecular Weight]
497.57 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [color ]
pale yellow to yellow-orange | [InChIKey]
ZWWMEDURALZMEV-NSHDSACASA-N | [SMILES]
O=C(N[C@H](C(O)=O)CCCNC(N)=N)C1=C(C=CS1)NS(C2=CC=CC3=NSN=C32)(=O)=O |
| Hazard Information | Back Directory | [Uses]
EG 00229 is a useful intermediate. | [Definition]
ChEBI: EG00229 is a member of the class of thiophenes that is thiophene substituted by a carbonyl-L-arginine and (2,1,3-benzothiadiazole-4-sulfonyl)amino groups at positions 2 and 3. It is an inhibitor of the neuropilin-1 and VEGF-A interaction and a potential anti-cancer agent. It has a role as an antineoplastic agent, a neuropilin receptor antagonist and an angiogenesis inhibitor. It is a benzothiadiazole, a sulfonamide, a member of thiophenes, a secondary carboxamide, a L-arginine derivative and a dicarboxylic acid monoamide. | [Biological Activity]
EG00229 is an antagonist of the VEGF-A receptor neuropilin 1 (NRP1)which decreases viability of A549 lung carcinoma cells. EG00229 impairs VEGFA induced migration of HUV-EC-C endothelial cells. |
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| Company Name: |
Energy Chemical
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| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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