| Identification | Back Directory | [Name]
4,4-(1E,1E)-2,2-(1-phenyl-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol) | [CAS]
1019110-87-2 | [Synonyms]
Phenol, 4,4'-[(1-phenyl-1H-pyrazole-3,5-diyl)di-(1E)-2,1-ethenediyl]bis[2-methoxy- | [Molecular Formula]
C27H24N2O4 | [MDL Number]
MFCD17019190 | [MOL File]
1019110-87-2.mol | [Molecular Weight]
440.49 |
| Chemical Properties | Back Directory | [Boiling point ]
646.4±55.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.87±0.31(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CNB-001 is a potent 5-lipoxygenase (5-LOX) inhibitor, decreases 5-LOX expression, and increases proteasome activity. CNB-001 also increases eIF2α phosphorylation and HSP90 and ATF4 levels in Alzheimer's disease transgenic mice, and limits the accumulation of soluble Aβ and ubiquitinated aggregated proteins. CNB-001 maintains the expression of synapse-associated proteins and improves memory. CNB-001 can be used for the research of Alzheimer's disease[1]. | [References]
[1] Valera E, et al. Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease. J Neurosci. 2013 Jun 19;33(25):10512-25. DOI:10.1523/JNEUROSCI.5183-12.2013 |
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| Company Name: |
3A Chemicals
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| Tel: |
400-668-9898 |
| Website: |
www.3achem.com |
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