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1019779-04-4

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1019779-04-4 Structure

1019779-04-4 Structure
IdentificationBack Directory
[Name]

GW791343 (HCl)
[CAS]

1019779-04-4
[Synonyms]

CS-196
GW 791343
GW791343 (HCl)
GW 791343 hydrochloride
GW 791343 dihydrochloride
GW791343 (dihydrochloride)
2-[(3,4-DIFLUOROPHENYL)AMINO]-N-[2-METHYL-5-(PIPERAZIN-1-YLMETHYL)PHENYL]ACETAMIDE
2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]acetamide hydrochloride
2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride
2-((3,4-difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride
[EINECS(EC#)]

200-258-5
[Molecular Formula]

C20H24F2N4O
[MDL Number]

MFCD12828767
[MOL File]

1019779-04-4.mol
[Molecular Weight]

374.428
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at RT
[solubility ]

H2O : 100 mg/mL (223.54 mM; Need ultrasonic)DMSO : 20 mg/mL (44.71 mM; Need ultrasonic)
[form ]

Powder
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

GW 791343 DTrihydrochloride is a P2X7 receptor antagonist that acts as an allosteric inhibitor, exhibiting negative allosteric effects at the human P2X7 receptor and positive allosteric effects at the rat P2X7 receptor. P2X7 receptor is responsible for the presence of inflammatory cells, regulated by extracellular ATP.
[IC 50]

P2X7 Receptor: 6.9-7.2 (pIC50)
Spectrum DetailBack Directory
[Spectrum Detail]

GW791343 (HCl)(1019779-04-4)1HNMR
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