| Identification | Back Directory | [Name]
protosappanin A | [CAS]
102036-28-2 | [Synonyms]
Sappanol B
protosappanin A
PROTOSAPPANIN A (PTA)
3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one
6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy- | [Molecular Formula]
C15H12O5 | [MDL Number]
MFCD28397928 | [MOL File]
102036-28-2.mol | [Molecular Weight]
272.25 |
| Chemical Properties | Back Directory | [Melting point ]
254-255 °C | [Boiling point ]
613.1±55.0 °C(Predicted) | [density ]
1.476±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.01±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3. | [Uses]
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1]. | [Definition]
ChEBI: A natural product found in Caesalpinia sappan. | [IC 50]
JAK2; STAT3 | [storage]
4°C, away from moisture and light | [References]
[1] Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15(9):674-679. DOI:10.1016/S1875-5364(17)30096-1
[2] Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14(4): 558- 569. DOI:10.1016/j.intimp.2012.09.004 |
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