| Identification | Back Directory | [Name]
EpigeneticMultipleLigand | [CAS]
1020399-52-3 | [Synonyms]
EpigeneticMultipleLigand
4H-Pyran-4-one, 3,5-bis[(3,5-dibromo-4-hydroxyphenyl)methylene]tetrahydro- | [Molecular Formula]
C19H12Br4O4 | [MDL Number]
MFCD28145786 | [MOL File]
1020399-52-3.mol | [Molecular Weight]
623.91 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes, including H4/PRMT1 (91% inhibition at 50 µM), H4/RmtA (50% inhibition at 29 µM), H3/p300/CBP (61% inhibition at 50 µM), PABP1/CARM1 (>90% inhibition at 100 µM), H3/SET7 (>90% inhibition at 100 µM), SIRT1/2 (>50% inhibition at 25 µM), although the process of Np13p by PRMT1 is only weakly affected. Shown to induce either apoptosis (28% after 30 h incubation with 25 µM inhibitor) or granulocytic differentiation (100% of non-apoptotic cells after 30 hr incubation with 5 µM inhibitor) among U937 cell population. |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
AstaTech, Inc
|
| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
|