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1020719-62-3

1020719-62-3 Structure

1020719-62-3 Structure
IdentificationBack Directory
[Name]

5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
[CAS]

1020719-62-3
[Synonyms]

AMR69 D5
[2H5]-Pirfenidone
2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-
2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-
Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one
5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone
[Molecular Formula]

C12H11NO
[MDL Number]

MFCD07369537
[MOL File]

1020719-62-3.mol
[Molecular Weight]

185.222
Chemical PropertiesBack Directory
[Melting point ]

104-106°C
[storage temp. ]

-20°C Freezer
[solubility ]

Chloroform (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly)
[form ]

Solid
[color ]

White to Light Beige
[InChI]

InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
[InChIKey]

ISWRGOKTTBVCFA-UHFFFAOYSA-N
[SMILES]

O=C1C=CC(C)=CN1C1C([H])=C([H])C([H])=C([H])C=1[H]
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
Hazard InformationBack Directory
[Description]

Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities. It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin . In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively). Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
[Chemical Properties]

Off-White Solid
[Uses]

A deuterated metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.
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