| Identification | Back Directory | [Name]
TC-G 1003 | [CAS]
1021912-42-4 | [Synonyms]
TC-G 1003
TCG1003,TC-G-1003
3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphenyl)-6-quinolinyl]phenol
Phenol, 3-[4-(3-aminopropoxy)-7-chloro-3-(3,5-dimethylphenyl)-6-quinolinyl]- | [Molecular Formula]
C26H25ClN2O2 | [MDL Number]
MFCD30182254 | [MOL File]
1021912-42-4.mol | [Molecular Weight]
432.94 |
| Hazard Information | Back Directory | [Uses]
TC-G 1003 is a selective somatostatin receptor subtype 2 agonist. | [in vivo]
sst2 Receptor agonist-1 (compound 21) (0.2 or 2 mg/kg; IV; single dosage) shows a dose-dependent decrease in growth hormone (GH) secretion[1].
sst2 Receptor agonist-1 (5 or 15 μg/per eye; intraocular; once every 4 days) reduces neovascular lesion area in laser choroidal neovascularization (CNV) rat model[1].
Pharmacokinetic Parameters of sst2 Receptor agonist-1 (compound 21) in dogs and rats[1].
| species | dog (IV 0.125 mg/kg) | rat (IV 2 mg/kg or 5 mg/kg) | | CLplasma (mL/min/kg) | 7.1 | 52 | | t1/2 (h) | 11 | 2.9 | | VdSS (L/kg) | 5.7 | 9.4 | | F (%) | ND | 17 |
| Animal Model: | Female Wistar rats (200-250 g; IP injection with 50 mg/kg pentobarbital, then injected with tested compound via jugular cannula, after 40 or 50 min administration, injected with GH secretagogue via jugular cannula)[1] | | Dosage: | 0.2 or 2 mg/kg | | Administration: | IV; single dosage | | Result: | Caused a dose-dependent decrease in GH secretion (38 and 91% reduction in plasma GH AUC following administration of 0.2 and 2 mg/kg, respectively). |
| Animal Model: | Male Brown Norway rats (175-225 g; lasered and perfused, a 27G needle was used to make a small hole in the eye 3 mm posterior to iris angled 45° toward the optic nerve)[1] | | Dosage: | 5 or 15 μg/per eye, 5 μL | | Administration: | Intraocular administration; inject at day 0, 4 and 8 | | Result: | Exhibited a dose-dependent antiangiogenic effect by a 35 and 53% reduction in neovascular lesion area with 5 or 15 μg per eye, respectively. |
| [IC 50]
SSTR2: 0.025 nM (Ki); SSTR2: 4.8 nM (IC50) |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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