| Identification | Back Directory | [Name]
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE | [CAS]
1021950-79-7 | [Synonyms]
Trolline
Oleracein E
Trolline（(±)-Trolline）
Trolline((±)-Trolline)
8,9-DIHYDROXY-1,5,6,10B-TETRAHYDROPYRROLO[2,1-A]ISOQUINOLIN-3(2H)-ONE
Pyrrolo[2,1-a]isoquinolin-3(2H)-one, 1,5,6,10b-tetrahydro-8,9-dihydroxy- | [Molecular Formula]
C12H13NO3 | [MDL Number]
MFCD22690448 | [MOL File]
1021950-79-7.mol | [Molecular Weight]
219.24 |
| Hazard Information | Back Directory | [Description]
Oleracein E is a a tetrahydroisoquinoline possessing potent antioxidant activity. Pretreatment with OE (10 μM, 2 h) decreased lactic acid dehydrogenase (LDH) release and the apoptosis rate in rotenone (5 μM, 24 h)-treated SH-SY5Y human neuroblastoma cells. Further mechanistic study indicated that OE reduced reactive oxygen species (ROS) levels, inhibited extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, reduced rotenone-induced up-regulation of the proapoptotic protein Bax, and prevented cytochrome C release and caspase-3 activation. | [Uses]
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis[1]. | [References]
[1] Bai F, et, al. Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy. Cell Physiol Biochem. 2017;44(2):436-446. DOI:10.1159/000485009 |
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