| Identification | Back Directory | [Name]
1-Piperidinecarboxylic acid, 4-[[[(3,5-dichlorophenyl)amino]thioxomethyl]amino]-, ethyl ester | [CAS]
1022367-69-6 | [Synonyms]
TT01001
TT01001 >=98% (HPLC)
1-Piperidinecarboxylic acid, 4-[[[(3,5-dichlorophenyl)amino]thioxomethyl]amino]-, ethyl ester | [Molecular Formula]
C15H19Cl2N3O2S | [MDL Number]
MFCD28502282 | [MOL File]
1022367-69-6.mol | [Molecular Weight]
376.3 |
| Chemical Properties | Back Directory | [Boiling point ]
474.5±55.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
Solid | [pka]
11.55±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TT01001 is a potent and orally active mitoNEET ligand. TT01001 reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 improves type II diabetes without causing weight gain[1][2]. | [Biological Activity]
TT01001 is potentorally available the mitochondrial outer membrane protein mitoNEET ligands th at binds to mitoNEET without PPARγ activation. TT01001 improves hyperglycemiahyperlipidemiaand glucose intolerance in mice models of diabetes II. TT01001 exerts anti-diabetic effects without the pioglitazone associated weight gain. | [References]
[1] Takehiro Takahashi, et al. A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice. J Pharmacol Exp Ther. 2015, 352, 2. DOI:10.1124/jpet.114.220673
[2] Shi G, et al. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage in rats. Neuroreport. 2020;31(11):845-850. DOI:10.1097/WNR.0000000000001492 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|