| Identification | Back Directory | [Name]
1-Piperazinecarboxamide, 4-(5-cyano-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]- | [CAS]
1024168-48-6 | [Synonyms]
Pantothenate kinase-IN-1
1-Piperazinecarboxamide, 4-(5-cyano-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]- | [Molecular Formula]
C21H25N5O | [MOL File]
1024168-48-6.mol | [Molecular Weight]
363.46 |
| Hazard Information | Back Directory | [Uses]
Pantothenate kinase-IN-1 (Compound 1) is a pantothenate kinase (PANK) modulator with an IC50 of 0.51 μM against PANK3. Pantothenate kinase-IN-1 has a reasonable ligand efficiency (LipE = 2.8)[1]. | [References]
[1] Sharma LK, et al. LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators. Bioorg Med Chem. 2021 Dec 15;52:116504. DOI:10.1016/j.bmc.2021.116504 |
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