| Identification | Back Directory | [Name]
6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- | [CAS]
1026876-55-0 | [Synonyms]
AMG7905
6-Benzothiazolamine, N-[6-[2-[(cyclohexylmethyl)amino]-4-(trifluoromethyl)phenyl]-4-pyrimidinyl]- | [Molecular Formula]
C25H24F3N5S | [MDL Number]
MFCD17166994 | [MOL File]
1026876-55-0.mol | [Molecular Weight]
483.55 |
| Hazard Information | Back Directory | [Description]
AMG7905 is a transient receptor potential vanilloid type 1 modulator. | [Uses]
AMG 7905 is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2]. | [References]
[1] Garami A, et al. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf). 2018 Jul;223(3):e13038. DOI:10.1111/apha.13038
[2] Lehto SG, et al. Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008 Jul;326(1):218-29. DOI:10.1124/jpet.107.132233 |
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