| Identification | Back Directory | [Name]
8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine | [CAS]
1027513-54-7 | [Synonyms]
PSB 0788
8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
1H-Purine-2,6-dione, 8-[4-[[4-[(4-chlorophenyl)methyl]-1-piperazinyl]sulfonyl]phenyl]-3,9-dihydro-1-propyl- | [Molecular Formula]
C25H27ClN6O4S | [MOL File]
1027513-54-7.mol | [Molecular Weight]
543.04 |
| Chemical Properties | Back Directory | [Melting point ]
>292 °C (decomp) | [density ]
1.414±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble in DMSO > 10 mM | [form ]
Powder | [pka]
7.37±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases[1]. | [storage]
Store at 4°C | [References]
[1] Thomas Borrmann, et al. 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J Med Chem. 2009 Jul 9;52(13):3994-4 DOI:10.1021/jm900413e |
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BOC Sciences
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