| Identification | Back Directory | [Name]
1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl- | [CAS]
1029008-71-6 | [Synonyms]
3-arylisoquinolinamine derivative
1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl-
3 arylisoquinolinamine derivative,3arylisoquinolinamine derivative | [Molecular Formula]
C18H19N3O | [MOL File]
1029008-71-6.mol | [Molecular Weight]
293.36 |
| Chemical Properties | Back Directory | [Boiling point ]
504.9±50.0 °C(Predicted) | [density ]
1.190±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 50 mg/mL (170.44 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
7.53±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
3-arylisoquinolinamine derivative is a 3-arylisoquinolinamine derivative with antitumor activity. | [in vivo]
3-arylisoquinolinamine derivative (Compound 13) has higher antitumor efficacy (69.2 % inhibition) than that of the control drug, Paclitaxel (48.8 % inhibition) in the inhibition of growth of tumor in an animal model[2]. | [storage]
Store at -20°C | [References]
[1] Yang SH, et al. Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5277-81. DOI:10.1016/j.bmcl.2010.06.132
[2] Young Bok Lee, et al. 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents. WO 2008063548 A2. |
|
|