| Identification | Back Directory | [Name]
7-Octynoic acid | [CAS]
10297-09-3 | [Synonyms]
7-Octynoic acid
oct-7-ynoic acid
WJBHDZBQZOMDFF-UHFFFAOYSA-N | [Molecular Formula]
C8H12O2 | [MDL Number]
MFCD19228078 | [MOL File]
10297-09-3.mol | [Molecular Weight]
140.18 |
| Chemical Properties | Back Directory | [Melting point ]
19°C | [Boiling point ]
290.64°C (rough estimate) | [density ]
1.0450 (rough estimate) | [refractive index ]
1.4502 | [solubility ]
DMSO: 150 mg/mL (1070.05 mM) | [form ]
Liquid | [pka]
4.74±0.10(Predicted) | [color ]
Colorless to light pink | [Water Solubility ]
Water: 5 mg/mL (35.67 mM) |
| Hazard Information | Back Directory | [Uses]
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Definition]
ChEBI: 7-octynoic acid is a medium-chain fatty acid. | [IC 50]
Alkyl-Chain | [References]
[1] Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. DOI:10.1016/j.ccell.2019.10.002 |
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