| Identification | Back Directory | [Name]
Ralimetinib | [CAS]
1029939-86-3 | [Synonyms]
OZ439
Ralimetinib
Artefenomel
(OZ439)
XLCNVWUKICLURR-UHFFFAOYSA-N
Morpholine, 4-[2-(4-cis-dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decan]-4-ylphenoxy)ethyl]- | [Molecular Formula]
C28H39NO5 | [MDL Number]
MFCD28902251 | [MOL File]
1029939-86-3.mol | [Molecular Weight]
469.61 |
| Chemical Properties | Back Directory | [Melting point ]
152-154 °C | [Boiling point ]
608.7±55.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 10 mM | [form ]
A solid | [pka]
6.46±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2]. | [IC 50]
Plasmodium | [References]
[1] Jo?lle Jourdan, et al. Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel). ACS Infect Dis. 2016 Jan 8;2(1):54-61. DOI:10.1021/acsinfecdis.5b00090
[2] Tania Massignan, et al. Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2.
[3] Robert L Clark, et al. Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Birth Defects Res. 2018 Apr 17;110(7):553-578. DOI:10.1002/bdr2.1170 |
|
|