| Identification | Back Directory | [Name]
CMP5 | [CAS]
1030021-40-9 | [Synonyms]
CMP5
CMP-5 hydrochloride
CMP-5 hydrochloride
(PRMT5-IN-5) | [Molecular Formula]
C21H22ClN3 | [MDL Number]
MFCD07168944 | [MOL File]
1030021-40-9.mol | [Molecular Weight]
351.88 |
| Hazard Information | Back Directory | [Description]
CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 μM. CMP-5 shows promise as a novel therapeutic_x000D_
approach for B-cell lymphomas. | [Uses]
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2]. | [References]
[1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.?2017?Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702 |
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| Company Name: |
BOC Sciences
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| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
PHARMEKS Ltd.
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| Tel: |
+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
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