| Identification | Back Directory | [Name]
1H-Pyrrole-3-sulfonamide, 1,2-dimethyl-N-(5-methyl-3-isoxazolyl)-5-[4-methyl-5-[(4-methyl-1-piperidinyl)carbonyl]-2-thiazolyl]- | [CAS]
1030133-34-6 | [Synonyms]
Cas9-IN-2
1H-Pyrrole-3-sulfonamide, 1,2-dimethyl-N-(5-methyl-3-isoxazolyl)-5-[4-methyl-5-[(4-methyl-1-piperidinyl)carbonyl]-2-thiazolyl]- | [Molecular Formula]
C21H27N5O4S2 | [MOL File]
1030133-34-6.mol | [Molecular Weight]
477.6 |
| Hazard Information | Back Directory | [Uses]
Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1]. | [References]
[1] Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65(4):3266-3305. DOI:10.1021/acs.jmedchem.1c01834 |
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