| Hazard Information | Back Directory | [Description]
B 746 is an antibacterial agent primarily used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance. | [Uses]
B746 is a clofazimine analog with anti-Mycobacterium avium complex (MAC) activity and is less effective when used with clofazimine or streptomycin[1]. | [in vivo]
B746 (p.o.; 10, 20, 30 mg/kg; single dose; first day and 2, 4 and 6 weeks) inhibits Mycobacterial growth in spleen of beige mice[1]. | Animal Model: | beige mice | | Dosage: | 10, 20, 30 mg/kg | | Administration: | p.o.; 10, 20, 30 mg/kg; single dose; first day and 2, 4 and 6 week after infection | | Result: | Reduced Colony Forming Units (CFU) counts of Mycobacteria in spleen of beige mice. |
| [References]
[1] Gangadharam PR, et al. In vitro, in vivo, and intracellular chemotherapeutic activity of B746, a clofazimine analogue against Mycobacterium avium complex. Tuber Lung Dis. 1992 Aug;73(4):192-9. DOI:10.1016/0962-8479(92)90085-x |
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