| Chemical Properties | Back Directory | [Boiling point ]
540.7±50.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.72±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
A-935142 is a novel hERG channel activator. | [Uses]
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization[1][2]. | [References]
[1] Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. DOI:10.1080/00498254.2018.1449269
[2] Liu X, et al.Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers. Life Sci. 2012 Apr 20;90(15-16):607-11. DOI:10.1016/j.lfs.2012.02.017 |
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