| Identification | Back Directory | [Name]
GUANOSINE 5'-DIPHOSPHATE TRIS SALT | [CAS]
103192-39-8 | [Synonyms]
GUANOSINE 5'-DIPHOSPHATE TRIS SALT
GUANOSINE 5'-DIPHOSPHATE TRIS TYPE VI
guanosine 5'-diphosphate tris salt, Type VI
guanosine 5'-diphosphate tris salt from saccharomyces cerevisiae
Guanosine 5′-diphosphate tris salt from Saccharomyces cerevisi&Æ
Guanosine 5'-diphosphate tris salt from Saccharomyces cerevisiae Type VI, >=92.5%
[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1~{H}-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate | [Molecular Formula]
C14H26N6O14P2 | [MDL Number]
MFCD00058344 | [MOL File]
103192-39-8.mol | [Molecular Weight]
564.34 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [InChIKey]
YWMHXINREUQYRO-GWTDSMLYSA-N | [SMILES]
NC(CO)(CO)CO.NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1 |
| Hazard Information | Back Directory | [Uses]
Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI)[1][2]. | [Biochem/physiol Actions]
Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases. | [IC 50]
Human Endogenous Metabolite | [References]
[1] S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. DOI:10.1113/jphysiol.1991.sp018885
[2] Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. DOI:10.1038/srep40097 |
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