| Hazard Information | Back Directory | [Uses]
A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM. | [in vivo]
Both MK-2206 doses (oral gavage; 480 mg/kg once a week and 240 mg/kg three times a week; for 2 weeks) can inhibit the growth of human CNE-2 xenografts in nude mice. No other obvious toxicity is observed in mice[3].
MK-2206 (orally; 120 mg/kg; alternate days; for 3 weeks) significantly inhibits tumor growth in 3-5 week old athymic nude mice with GEO colon carcinoma cells[4]. | Animal Model: | Four- to 6-week-old male BALB/c nude mice with CNE-2 xenografts[3] | | Dosage: | 240 mg/kg and 480 mg/kg | | Administration: | Oral gavage; 240 mg/kg for three times a week; 480 mg/kg for once a week; for 2 weeks | | Result: | Both doses inhibited the growth of human CNE-2 xenografts in nude mice. |
| [IC 50]
Akt1: 8 nM (IC50); Akt2: 12 nM (IC50); Akt3: 65 nM (IC50) |
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| Company Name: |
Enzo Biochem Inc
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| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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