| Identification | Back Directory | [Name]
L-655,240 | [CAS]
103253-15-2 | [Synonyms]
L-655,240
JLPYLHLUHJOPNL-UHFFFAOYSA-N
1-(4-Chlorobenzyl)-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
1-[(4-CHLOROPHENYL)METHYL]-5-FLUORO-A,A,3-TRIMETHYL-1H-INDOLE-2-PROPANOIC ACID
3-[1-(4-CHLOROBENZYL)-5-FLUORO-3-METHYL-INDOL-2-YL]-2,2-DIMETHYL PROPANOIC ACID
1-((4-Chlorophenyl)methyl)-5-fluoro-alpha,alpha-3-trimethyl-(1H)-indole-2-propanoicacid | [Molecular Formula]
C21H21ClFNO2 | [MDL Number]
MFCD04040005 | [MOL File]
103253-15-2.mol | [Molecular Weight]
373.85 |
| Chemical Properties | Back Directory | [Boiling point ]
548.7±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: 30 mg/mL
| [form ]
solid
| [pka]
4.82±0.10(Predicted) | [color ]
off-white
|
| Hazard Information | Back Directory | [Biological Activity]
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist. pA 2 values are 8-8.4 in guinea pig smooth muscle; IC 50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo . | [Uses]
L-655,240 is a selective and potent thromboxane and prostaglandin endoperoxide antagonist. Also used in the structure-based and ligand-based drug design for microsomal prostaglandins E synthase-1 inhibitors. | [Definition]
ChEBI: 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methyl-2-indolyl]-2,2-dimethylpropanoic acid is a methylindole. | [in vivo]
L 655240 (0.3 mg/kg; i.v.; single dose) changes heat rate, arterial and pulmonary arterial blood pressure, and cardiac output in canine model[1].
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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