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Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research[1]. | [in vivo]
Quercetin 3-(6″-caffeoylsophoroside) (50, 100, 500, 1000, and 2000 mg/kg, p.o.) shows safety in acute oral toxicity of SD rats and can be used in anti-diabetic research[1].
Quercetin 3-(6″-caffeoylsophoroside) (125, 250, 500 mg/kg, p.o.) improves type 2 diabetes mellitus of SD rats by oxidative stress reduction and α-amylase inhibition[1].
| Animal Model: | FED HFD (45% fat) for 30 days to induce type 2 diabetes mellitus in SD rats[1] | | Dosage: | 125, 250, 500 mg/kg | | Administration: | Oral gavage (p.o.) | | Result: | Significantly decreased the blood glucose level, improved biochemical parameters as well as oxidative stress by reduction of lipid peroxidation, and increased high-density lipoproteins with dose of 500mg/kg.
Enhanced activities of glutathione-s-transferase, glutathione, superoxide dismutase.
Restored cellular architecture in the histopathological examination.
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| Animal Model: | Acute oral toxicity in 8-week male SD rats[1] | | Dosage: | 50, 100, 500, 1000, and 2000 mg/kg | | Administration: | Oral gavage (p.o.) | | Result: | Safe for use in anti-diabetic research.
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| [References]
[1] Malik A, et.al. In Vitro, In Silico, and In Vivo Studies of Cardamine hirsute Linn as a Potential Antidiabetic Agent in a Rat Model. ACS Omega. 2023 Jun 12;8(25):22623-22636. DOI:10.1021/acsomega.3c01034 |
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