| Identification | Back Directory | [Name]
[(2R)-2-[[(2S)-2-[[(2S)-2-amino-3-thiophen-2-yl-propanoyl]amino]-3-hyd roxy-propanoyl]amino]-3-phenyl-propanoyl] (2R,4S)-4-[[(2S)-6-amino-2-[ [(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]-2-[[(2S)-2-amino-3-(4- hydroxythiophen-2-yl)propanoyl]-[2-[[(2S)-1-[(2S)-pyrrolidine-2-carbon yl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-7-(diaminomethylideneami no)-2-[3-(diaminomethylideneamino)propyl]-3-oxo-heptanoate | [CAS]
103412-37-9 | [Synonyms]
B 4148
L-Arginine, L-lysyl-L-lysyl-L-arginyl-(4R)-4-hydroxy-L-prolyl-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-phenylalanyl-3-(2-thienyl)-L-alanyl- (9CI)
[(2R)-2-[[(2S)-2-[[(2S)-2-amino-3-thiophen-2-yl-propanoyl]amino]-3-hyd roxy-propanoyl]amino]-3-phenyl-propanoyl] (2R,4S)-4-[[(2S)-6-amino-2-[ [(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]-2-[[(2S)-2-amino-3-(4- hydroxythiophen-2-yl)propanoyl]-[2-[[(2S)-1-[(2S)-pyrrolidine-2-carbon yl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-7-(diaminomethylideneami no)-2-[3-(diaminomethylideneamino)propyl]-3-oxo-heptanoate | [Molecular Formula]
C62H95N19O14S2 | [MOL File]
103412-37-9.mol | [Molecular Weight]
1394.68 |
| Hazard Information | Back Directory | [Uses]
B4148 is a selective competitive bradykinin (BK) antagonist that significantly inhibits BK-induced hypotension in rats. In a rat model of endotoxin shock induced by Escherichia coli lipopolysaccharide, B4148 significantly attenuated the decrease in mean arterial blood pressure compared with the control group[1]. | [References]
[1] Endotoxin shock in the rat: reduction of arterial blood pressure fall by the bradykinin antagonist B4148. |
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