| Identification | Back Directory | [Name]
dynorphin A ethylamide (1-9), MeTyr(1)-MeArg(7)-Leu(8)- | [CAS]
103614-28-4 | [Synonyms]
Daeatal
dynorphin A ethylamide (1-9), MeTyr(1)-MeArg(7)-Leu(8)-
L-Argininamide, N-methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-N2-methyl-L-arginyl-D-leucyl-N-ethyl- (9CI) | [Molecular Formula]
C56H93N19O10 | [MOL File]
103614-28-4.mol | [Molecular Weight]
1192.46 |
| Hazard Information | Back Directory | [Description]
Dynorphin A ethylamide (1-9), The opioid activities were examined in the bioassays (guinea pig ileum, mouse vas deferens and rabbit vas deferens). the extension of the C-terminal in the peptide chain of [MeArg7,D-Leu8]-Dyn(1-8)-NH2 analogues by Arg is ineffective for increasing the kappa-opioid activities, kappa-receptor selectivity and/or analgesic effects of the peptides. | [Uses]
Daeatal (Dynorphin A ethylamide (1-9)) is an ethylamine-modified dynorphin fragment that can be used in the study of analgesia, addiction, depression, etc. Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease[1]. | [References]
[1] Hauser KF, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75. DOI:10.1006/exnr.1999.7235 |
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