| Identification | Back Directory | [Name]
L-Isoleucine, N-[(3R)-3-hydroxy-1-oxohexadecyl]-L-α-glutamyl-D-ornithyl-L-tyrosyl-D-allothreonyl-L-α-glutamyl-D-alanyl-L-prolyl-L-glutaminyl-D-tyrosyl-, (10→3)-lactone | [CAS]
103651-09-8 | [Synonyms]
Plipastatin A1
L-Isoleucine, N-[(3R)-3-hydroxy-1-oxohexadecyl]-L-α-glutamyl-D-ornithyl-L-tyrosyl-D-allothreonyl-L-α-glutamyl-D-alanyl-L-prolyl-L-glutaminyl-D-tyrosyl-, (10→3)-lactone | [Molecular Formula]
C72H110N12O20 | [MOL File]
103651-09-8.mol | [Molecular Weight]
1463.72 |
| Chemical Properties | Back Directory | [Boiling point ]
1693.7±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [pka]
4.45±0.10(Predicted) | [Sequence]
{(3R)-3-hydroxy-1-oxohexadecyl}-Glu-{d-Orn}-Tyr-{d-Thr}-Glu-{d-Ala}-Pro-Gln-{d-Tyr}-Ile (Lactam bridge: Tyr3-Ile10) |
| Hazard Information | Back Directory | [Uses]
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD[1]. | [References]
[1] Honma M, et al. Termination of the structural confusion between plipastatin A1 and fengycin IX. Bioorg Med Chem. 2012 Jun 15;20(12):3793-8. DOI:10.1016/j.bmc.2012.04.040 |
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