| Identification | Back Directory | [Name]
C450-0730 | [CAS]
1036730-46-7 | [Synonyms]
C450-0730
2-(1-Acetylindoline-5-sulfonamido)-N-(4-chlorobenzyl)-4-methylpentanamide
Pentanamide, 2-[[(1-acetyl-2,3-dihydro-1H-indol-5-yl)sulfonyl]amino]-N-[(4-chlorophenyl)methyl]-4-methyl- | [Molecular Formula]
C23H28ClN3O4S | [MOL File]
1036730-46-7.mol | [Molecular Weight]
478 |
| Chemical Properties | Back Directory | [density ]
1.292±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Solid | [pka]
9.05±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
C450-0730 is an antagonist targeting the AHL membrane-bound sensor kinase and is an antagonist of the nine-transmembrane protein LuxN of Vibrio harveyi . C450-0730 competitively binds to the LuxN AI-1 binding site and specifically antagonizes the LuxN/AI-1 quorum sensing signal in Vibrio harveyi. The inhibitory activity of C450-0730 against LuxNI209F was not significant[1]. | [References]
[1] Swem LR, et al. Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell. 2008 Aug 8;134(3):461-73. DOI:10.1016/j.cell.2008.06.023 |
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