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1036915-08-8

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1036915-08-8 Structure

1036915-08-8 Structure
IdentificationBack Directory
[Name]

IDX-184
[CAS]

1036915-08-8
[Synonyms]

IDX-184
2'-C-Methylguanosine 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
Guanosine, 2'-C-methyl-, 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]
[Molecular Formula]

C25H35N6O9PS
[MDL Number]

MFCD23381633
[MOL File]

1036915-08-8.mol
[Molecular Weight]

626.62
Chemical PropertiesBack Directory
[Boiling point ]

879.9±75.0 °C(Predicted)
[density ]

1.59
[form ]

Solid
[pka]

13.19±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM)[1][2].
[References]

[1] Xiao-Jian Zhou , et al. Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects. Antimicrob Agents Chemother. 2011 Jan;55(1):76-81. DOI:10.1128/AAC.01101-10
[2] IN VITRO ANTIVIRAL ACTIVITY AND PHARMACOLOGY OF IDX184, A NOVEL AND POTENT INHIBITOR OF HCV REPLICATION.
Spectrum DetailBack Directory
[Spectrum Detail]

IDX-184(1036915-08-8)1HNMR
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