| Identification | Back Directory | [Name]
Pentadecylidenemalonate 1b | [CAS]
1036939-38-4 | [Synonyms]
SPV-106
SPV-106,SPV106
SPV-106 >=98% (HPLC)
Pentadecylidenemalonate 1b
1,3-diethyl 2-pentadecylidenepropanedioate
2-Pentadecylidene-Propanedioic acid 1,3-diethyl ester
Propanedioic acid, 2-pentadecylidene-, 1,3-diethyl ester | [Molecular Formula]
C22H40O4 | [MDL Number]
MFCD20527327 | [MOL File]
1036939-38-4.mol | [Molecular Weight]
368.55 |
| Chemical Properties | Back Directory | [Boiling point ]
419.2±18.0 °C(Predicted) | [density ]
0.940±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
oil | [color ]
colorless | [InChI]
1S/C22H40O4/c1-4-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21(23)25-5-2)22(24)26-6-3/h19H,4-18H2,1-3H3 | [InChIKey]
APIJHPAXMCKJBY-UHFFFAOYSA-N | [SMILES]
CCCCCCCCCCCCCC\C=C(\C(=O)OCC)C(=O)OCC |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
43 | [Safety Statements ]
36/37 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Skin Sens. 1 |
| Hazard Information | Back Directory | [Uses]
SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D)[1]. | [Biological Activity]
SPV106 is a mixed inhibitor/activator of histone acetyltransferase (HAT) activity. The compound inhibits the activity of p300/CBPbut potentiates p300/CBP-associated factor (PCAF) activity. SPV106 also induces S-phase cell cycle arrest and apoptosis in U937 cells. | [References]
[1] Matteo Vecellio, et al. The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients. Diabetes. 2014 Jun;63(6):2132-47. DOI:10.2337/db13-0731 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|