| Identification | Back Directory | [Name]
MOEXIPRILAT HYDRATE | [CAS]
103775-14-0 | [Synonyms]
RS 10029 Moexiprilat Moexipril Related CoMpound A 2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic Acid Hydrate (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid (3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-(phenyl-d5)propyl]aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid [3S-[2[R*(R*)],3R*]]-2-[2-[(1-
Carboxy-3-phenylpropyl)aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid [3S-[2[R*(R*)],3R*]]-2-[2-[(1-
Carboxy-3-(phenyl-d5)propyl)aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid | [Molecular Formula]
C25H30N2O7 | [MDL Number]
MFCD00865812 | [MOL File]
103775-14-0.mol | [Molecular Weight]
470.51 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
145-1700C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO: soluble Methanol: soluble |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
Analogue of Quinapril | [Uses]
Angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of Quinapril. Antihypertensive. | [References]
[1] O EDLING. Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 275 2: 854-863.
[2] RYAN T. CAMERON . Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)[J]. Biochemical pharmacology, 2013, 85 9: Pages 1297-1305. DOI: 10.1016/j.bcp.2013.02.026 [3] C GROHÉ. Angiotensin converting enzyme inhibition modulates cardiac fibroblast growth.[J]. Journal of Hypertension, 1998, 16 3: 377-384. DOI: 10.1097/00004872-199816030-00015 [4] VAN EICKELS MARTIN. The influence of oestrogen-deficiency and ACE inhibition on the progression of myocardial hypertrophy in spontaneously hypertensive rats[J]. European Journal of Heart Failure, 2005, 7 7: 1079-1084. DOI: 10.1016/j.ejheart.2005.03.004 |
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