| Identification | Back Directory | [Name]
1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- | [CAS]
1037837-27-6 | [Synonyms]
1H-Indole-5-carboxamide, 1-[1-[2-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo- | [Molecular Formula]
C24H32N4O3 | [MOL File]
1037837-27-6.mol | [Molecular Weight]
424.54 |
| Chemical Properties | Back Directory | [Boiling point ]
686.8±55.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [solubility ]
DMSO:2.12(Max Conc. mg/mL);5.0(Max Conc. mM)
Ethanol:21.23(Max Conc. mg/mL);50.0(Max Conc. mM) | [form ]
Solid | [pka]
14.81±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes. | [Uses]
ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research[1]. | [IC 50]
IL-1β; iNOS; COX-2 | [References]
[1] De Vita T, et al. Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury. ACS Chem Neurosci. 2019 Mar 20;10(3):1627-1635. DOI:10.1021/acschemneuro.8b00556 |
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