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AD-5075 is an orally active insulin sensitizer. AD-5075 mediates its antidiabetic activity by binding to PPARγ and thereby generating an active conformation of the receptor[1]. | [References]
[1] Berger J, et al. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice[J]. Endocrinology, 1996, 137(10): 4189-4195. DOI:10.1210/endo.137.10.8828476 |
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