| Identification | Back Directory | [Name]
6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole | [CAS]
1038408-36-4 | [Synonyms]
6-Bromo-1-isopropyl-2-methyl-1H-benzimidazole
6-BroMo-1-isopropyl-2-Methyl-1H-benzoiMidazole
6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole
6-Bromo-2-methyl-1-(1-methylethyl)-1H-benzimidazole
1H-BenziMidazole, 6-broMo-2-Methyl-1-(1-Methylethyl)- | [Molecular Formula]
C11H13BrN2 | [MDL Number]
MFCD11113090 | [MOL File]
1038408-36-4.mol | [Molecular Weight]
253.14 |
| Chemical Properties | Back Directory | [Boiling point ]
353.9±15.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
5.20±0.10(Predicted) | [Appearance]
Light brown to brown Oil |
| Hazard Information | Back Directory | [Uses]
6-Bromo-2-methyl-1-(1-methylethyl)-1H-benzimidazole is used in preparation of Amino Pyrimidine compound for inhibiting protein Tyrosine kinase activity. | [Synthesis]
Part D: 5-Bromo-N1-isopropyl-1,2-benzenediamine (0.56 g, 2.45 mmol) was dissolved in glacial acetic acid (20 mL), heated to reflux and stirred for 2 hours. The completion of the reaction was confirmed by LC-MS analysis. The reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: 5% methanol/dichloromethane) to afford 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole (Compound 227) as a red oil in a yield of 0.55 g (90%).1H NMR (400 MHz, DMSO-d6) δ 7.82 (d,1H), 7.44 (1H) 7.24 (dd, 1H), 4.75 (m, 1H), 2.54 (s, 3H), 1.51 (d, 6H). | [References]
[1] Patent: WO2008/82487, 2008, A2. Location in patent: Page/Page column 110 |
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| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
parabiochem
|
| Tel: |
025-83453382-8005 |
| Website: |
www.parabiochem.cn |
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