| Identification | Back Directory | [Name]
LAZABEMIDE | [CAS]
103878-84-8 | [Synonyms]
LAZABEMIDE
Ro-19-6327
Ro 19-6327/000
Lazabemide hydrate
Ro 19-6327 hydrate
LAZABEMIDE HYDROCHLORIDE
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide
N-(2-aminoethyl)-5-chloropyridine-2-carboxamide
2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrate | [Molecular Formula]
C8H10ClN3O | [MDL Number]
MFCD00865419 | [MOL File]
103878-84-8.mol | [Molecular Weight]
199.64 |
| Chemical Properties | Back Directory | [Boiling point ]
397.4±37.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: ≥22mg/mL | [form ]
powder | [pka]
12.90±0.46(Predicted) | [color ]
white to tan | [InChI]
1S/C8H10ClN3O.H2O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H2 | [InChIKey]
JYWYNPKXSLPWGV-UHFFFAOYSA-N | [SMILES]
O.NCCNC(=O)c1ccc(Cl)cn1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-36 | [Safety Statements ]
26 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Lazabemide Monohydrochloride: C8H10ClN3O·HCl. [103878-83-7]. Crystallized from methanol-ether, melting point 193-195°C. Partition coefficient (n-octanol): approximately 0.1. pKa 8.9. Acute toxicity LD50 (mg/kg) in mice: 1000-2000 oral dose. | [Uses]
Treatment of Alzheimer’s disease. | [Brand name]
Tempium (Hoffmann-LaRoche). | [Biochem/physiol Actions]
Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation. |
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| Company Name: |
Finetech Industry Limited
|
| Telephone: |
+86-27-8746-5837 +86-18627785180 |
| Website: |
https://www.finetechnology-ind.com/ |
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