| Identification | Back Directory | [Name]
Mannioside A | [CAS]
1038922-95-0 | [Synonyms]
Mannioside A
(25R)-17α-hydroxyspirost-5-en-3β-yl O-α-L-rhamnopyranosyl-(1→3)-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl 3-O-(6-deoxy-α-L-mannopyranosyl)-
(3beta,25R)-17-Hydroxyspirost-5-en-3-yl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | [Molecular Formula]
C39H63O13 | [MDL Number]
MFCD20260832 | [MOL File]
1038922-95-0.mol | [Molecular Weight]
739.91 |
| Hazard Information | Back Directory | [Uses]
Mannioside A is a steroidal saponin. Mannioside A is a nature product that could be isolated from Dracaena mannii. Mannioside A has anti-inflammatory effect[1]. | [Definition]
ChEBI: Mannioside A is a steroid saponin that consists of pennogenin attached to alpha-L-rhamnopyranosyl-(1->3)-beta-D-glucopyranosyl residue at position 3 via a glycoidic linkage. Isolated from Dracaena mannii, it exhibits anti-inflammatory activity. It has a role as a metabolite and an anti-inflammatory agent. It is a 17alpha-hydroxy steroid, an organic heterohexacyclic compound, an oxaspiro compound, a disaccharide derivative and a steroid saponin. It is functionally related to a pennogenin. | [in vivo]
Mannioside A (compound 1; 10 mg/kg; p.o.) inhibits carrageene-induced paw edema in rats[1]. | Animal Model: | Wistar rats[1] | | Dosage: | 10 mg/kg | | Administration: | oral administration | | Result: | Had anti-inflammatory effects with maximum activity observed within 2 h. |
| [References]
[1] Tapondjou LA, et, al. In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii. Arch Pharm Res. 2008 May;31(5):653-8. DOI:10.1007/s12272-001-1208-3 |
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