ChemicalBook--->CAS DataBase List--->10391-08-9

10391-08-9

10391-08-9 Structure

10391-08-9 Structure
IdentificationBack Directory
[Name]

macrocalin A
[CAS]

10391-08-9
[Synonyms]

Isodocarpin
13-Deoxyenmein
(-)-Isodocarpin
(-)-Isodocarpin
(10bS)-1,2,3,3aβ,8,9,10,10aα,13,13aβ-Decahydro-13β-hydroxy-1,1-dimethyl-7-methylene-5H-5aβ,8β-methanocyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione
[Molecular Formula]

C12H26
[MOL File]

10391-08-9.mol
[Molecular Weight]

170.335
Chemical PropertiesBack Directory
[Melting point ]

270-273℃
[Boiling point ]

568.7±50.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
[pka]

12.83±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1].
[References]

[1] Yoshiaki Manse, et al. Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus. Natural Product Communications. August 1, 2017.
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