| Identification | Back Directory | [Name]
sepimostate mesilate | [CAS]
103926-82-5 | [Synonyms]
FUT-187
Sepinostat mesilate
Sepimostat Mesylate
sepimostate mesilate
Sepimostat (dimethanesulfonate ) | [Molecular Formula]
C21H19N5O2.2CH4O3S | [MOL File]
103926-82-5.mol | [Molecular Weight]
565.625 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P280-P301+P312-P302+P352-P305+P351+P338 | [Toxicity]
LD50 in male, female mice, male, female rats (mg/kg): 39.4, 41.4, 21.8, 15.8 i.v.; 6284, 5492, 6799, 3343 s.c.; 4395, 3626, 4653, 3761 orally (Terazawa) |
| Hazard Information | Back Directory | [Uses]
Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7?μM[1]. | [in vivo]
Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. | Animal Model: | Male Sprague Dawley rats weighing 150-300?g[1]. | | Dosage: | Intravitreal injection. | | Administration: | 1 to 100 nmol/eye. | | Result: | Exhibited neuroprotective effects significantly. |
| [References]
[1] Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409. DOI:10.1038/s41598-019-56905-x |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|