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103978-08-1

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103978-08-1 Structure

103978-08-1 Structure
IdentificationBack Directory
[Name]

CP 67804
[CAS]

103978-08-1
[Synonyms]

804
CP 67804
CCRIS 8213
CP67804,CP 67804
3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo-
[Molecular Formula]

C18H13F2NO4
[MDL Number]

MFCD00907884
[MOL File]

103978-08-1.mol
[Molecular Weight]

345.3
Chemical PropertiesBack Directory
[Boiling point ]

526.5±50.0 °C(Predicted)
[density ]

1.456±0.06 g/cm3(Predicted)
[pka]

-1.06±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent[1].
[IC 50]

Topoisomerase II
[References]

[1] Robinson MJ, et al. Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage. J Biol Chem. 1991;266(22):14585-14592. PMID:1650363
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