| Identification | Back Directory | [Name]
MCH-1 antagonist 1 | [CAS]
1039825-68-7 | [Synonyms]
MCH-1 antagonist 1
2(1H)-Pyridinone, 4-(phenylmethoxy)-1-[1-[2-(1-pyrrolidinyl)ethyl]-1H-indazol-5-yl]- | [Molecular Formula]
C25H26N4O2 | [MDL Number]
MFCD18633193 | [MOL File]
1039825-68-7.mol | [Molecular Weight]
414.5 |
| Hazard Information | Back Directory | [Uses]
MCH-1 Antagonist 1, is a potent melanin concentrating hormone (MCH-1) antagonist. | [in vivo]
MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1]. | [IC 50]
MCH-1: 2.6 nM (Ki); CYP3A4: 10 μM (IC50) |
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