| Identification | Back Directory | [Name]
Propamidine | [CAS]
104-32-5 | [Synonyms]
DAPP
Brolene
propamidine
4,4'-(1,3-Propanediyl)bis(oxy)bisbenzamidine
4,4'-[1,3-Propanediylbis(oxy)]dibenzenecarboximidamide
4,4'-[1,3-Propanediylbis(oxy)]bis(benzenecarbimidamide)
4,4'-(1,3-Propanediylbis(oxy))bisbenzenecarboximidamide
BenzenecarboxiMidaMide,4,4'-[1,3-propanediylbis(oxy)]bis- | [EINECS(EC#)]
203-195-2 | [Molecular Formula]
C17H20N4O2 | [MDL Number]
MFCD00866601 | [MOL File]
104-32-5.mol | [Molecular Weight]
312.37 |
| Hazard Information | Back Directory | [Uses]
as isethionate. | [Definition]
ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis. | [Production Methods]
Commercial production of propamidine follows the classic industrial route for generating aromatic diamidines from dinitrile precursors. Manufacturers begin with a bis substituted aromatic dinitrile, which is converted to the corresponding imidate ester under acidic alcoholysis. This activated intermediate is then reacted with propylamine, producing the bis amidine framework through sequential nucleophilic substitution. The process requires careful control of moisture and temperature to prevent hydrolysis and to ensure full conversion of both nitrile groups. After neutralisation and purification, the technical material is isolated as a stable salt suitable for downstream formulation. | [Pharmaceutical Applications]
A synthetic diamidine formulated as the isethionate or as
dibromopropamidine isethionate for topical administration
to the eye. Resistant clinical isolates of Acanthamoeba
have been identified. It is available over the counter in eye
drops.
Its activity against bacterial pathogens is poor, but it exhibits
specific activity against Acanthamoeba spp. Reduction in
sensitivity of Acanthamoeba during encystation might reflect
changes in drug uptake. It is still recommended for aggressive
treatment of amebic keratitis (in combination with neomycin
or other agents), but is not well tolerated. | [Mechanism of action]
Curative and protectant activity. Acts by disrupting cell membrane and thus causing leakage of essential amino acids from microbes | [Pesticide Type]
Fungicide; Antimicrobial |
|
| Company Name: |
Struchem Co., Ltd.
|
| Tel: |
0512-63009836 18994340901 |
| Website: |
http://www.beidapharma.com |
| Company Name: |
Alfa Chemistry
|
| Tel: |
+1-516-662-5404 |
| Website: |
www.alfa-chemistry.com |
|