| Identification | Back Directory | [Name]
SDZ NVI-085 | [CAS]
104195-17-7 | [Synonyms]
SDZ NVI-085
naphtoxazine
[4aR,(-)]-3,4,4aβ,5,10,10aα-Hexahydro-6-methoxy-4-methyl-9-methylthio-2H-naphth[2,3-b]-1,4-oxazine | [Molecular Formula]
C15H21NO2S | [MDL Number]
MFCD00897700 | [MOL File]
104195-17-7.mol | [Molecular Weight]
279.4 |
| Hazard Information | Back Directory | [Description]
SDZ-NVI-085, also known as Naphtoxazine, is an α1 adrenergic receptor agonist potentially for the treatment of cognitive disorders and major depressive disorder. SDZ-NVI-085 behaves as a competitive antagonist of 5-hydroxytryptamine. SDZ-NVI-085 shifted 5-HT concentration-effect curves to the right, in a concentration-dependent manner, and Schild regression gave a pA2 estimate of 8.0. | [Uses]
SDZ NVI 085 is a compound with CNS stimulatory effects, primarily through the α1-adrenoceptor subtype, with anti-cataplexy and anti-stroke activities. SDZ NVI 085 also has a significant alertness effect and can be used to study other types of excessive sleepiness[1]. | [References]
[1] A Renaud, et al. Effects of SDZ NVI-085, a putative subtype-selective α1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep. European journal of pharmacology 205.1 (1991): 11-16. DOI:10.1016/0014-2999(91)90763-g |
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