| Chemical Properties | Back Directory | [Boiling point ]
443.4±30.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.99±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1]. | [IC 50]
human PARP10: 3.64 μM (IC50); human PARP15: 11 μM (IC50); human PARP2: 27 μM (IC50); human PARP12: >10 μM (IC50); human PARP16: >10 μM (IC50); human PARP1: >100 μM (IC50); human PARP3: >100 μM (IC50); human PARP4: >100 μM (IC50); human TNKS1: >100 μM (IC50); human TNKS2: >100 μM (IC50); human PARP14: >100 μM (IC50) | [References]
[1] Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948. DOI:10.1002/open.202100087 |
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