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10436-21-2

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10436-21-2 Structure

10436-21-2 Structure
IdentificationBack Directory
[Name]

PROTAC Linker 32
[CAS]

10436-21-2
[Synonyms]

PROTAC Linker 32
Boc-NH-C6-amido-C4-acid
6-((6-((tert-butoxycarbonyl)amino)hexyl)amino)-6-oxohexanoic acid
Hexanoic acid, 6-[[6-[[(1,1-dimethylethoxy)carbonyl]amino]hexyl]amino]-6-oxo-
[Molecular Formula]

C17H32N2O5
[MDL Number]

MFCD32201088
[MOL File]

10436-21-2.mol
[Molecular Weight]

344.45
Chemical PropertiesBack Directory
[Melting point ]

107-108 °C
[Boiling point ]

571.6±35.0 °C(Predicted)
[density ]

1.069±0.06 g/cm3(Predicted)
[pka]

4.70±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
[IC 50]

Alkyl/ether
[References]

[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21. DOI:10.1021/acs.jmedchem.9b00919
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