| Identification | Back Directory | [Name]
Ceftriaxone sodium | [CAS]
104376-79-6 | [Synonyms]
Rosihlitazone
CEFTRIAXONE NA
RO-13-9904/001
Hemiheptahydrate
ROCEFIN ROCEPHINE
CEFTRIASONE SODIUM
CEFTRIAXONE SODIUM INJ
CEFTRIAXONE SODIUM SALT
CEFTRIAXONE SODIUM HYDRATE
Ceftriaxone sodium sterile
Ceftriaxone Sodium (350 mg)
Ceftriaxone SodiuM Trihydrate
CeftriaxoneSodiumSterileUsp26
Ceftriaxone Sodium(Nonsterile)
Disodium salt hemiheptahydrate
Ceftriaxone Disodium Salt
CEFTRIAXONE SODIUM FOR INJECTION
Ceftriaxone (sodium salt hydrate)
Ro-13-9904/001, Rocefin Rocephine
Ceftriaxone sodiuM sesquaterhydrate
CEFTRIAXONE, DISODIUM SALT, HEMIHEPTAHYDRATE
Ceftriaxone Sodium (350 mg)G1D265925ug/mg(an)
Ceftriaxone hemi(heptahydrate) disodium salt
Ceftriaxone disodium salt hemiheptahydrate, >=98%
(6r,7r)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
(6R,7R)-7-[(Z)-2-2(2-Amino-4-thiazolyl)-2-(methoxyimino)azetamido]-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-aza-bicyclo-[4.2.0]oct-2-en-2-carbonsure-dinatriumsalz
7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicaciddisodiumsalt
[6R-[6α,7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)- | [EINECS(EC#)]
277-930-0 | [Molecular Formula]
C18H16N8Na2O7S3.31/2H2O | [MDL Number]
MFCD01750405 | [MOL File]
104376-79-6.mol | [Molecular Weight]
598.54 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
236 °C | [alpha ]
D25 -165° (c = 1 in water) (calc for water-free substance) | [refractive index ]
-160 ° (C=1, H2O) | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble50mg/mL | [form ]
powder or crystals | [pka]
~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH) | [color ]
White to Off-White | [Water Solubility ]
Freely soluble in water | [Major Application]
pharmaceutical (small molecule) | [InChIKey]
FDRNWTJTHBSPMW-BBJOQENWSA-L | [SMILES]
C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NC(=O)C(=O)NN1C)(=O)O.[NaH].O |&1:5,7,r| |
| Questions And Answer | Back Directory | [Preparation]
process for preparing ceftriaxone sodium, under nitrogen protection, involves the reaction of 7-ACT and AE-active esters in a solvent under the action of amine intermediates, followed by the addition of a sodium salt-forming agent to precipitate crystals. The solvent is characterized by being a mixed solvent composed of alkyl halogenated hydrocarbons, ethyl acetate or acetone, alcohol solvents, and water. The reaction of 7-ACT and AE-active esters is stirred until clear, followed by the direct addition of a sodium salt-forming agent to initiate a salt-forming reaction. When the reaction solution becomes turbid, crystal growth is performed, followed by crystal precipitation using an insoluble organic solvent for ceftriaxone sodium. Finally, ceftriaxone sodium is obtained after conventional crystal washing and drying. |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
A potentially useful antibacterial agent for proteomics research. | [Uses]
An antibacterial, a third-generation cephalosporin. | [Uses]
antipsychotic | [Biological Activity]
β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter. | [Description]
Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.1,2,3 It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.4 | [Definition]
ChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin. | [Brand name]
Rocephin (Roche). | [storage]
Store at -20°C | [References]
[1] H. NEU F KWUNGP N Meropol. Antibacterial Activity of Ceftriaxone (Ro 13-9904), a β-Lactamase-Stable Cephalosporin[J]. Antimicrobial Agents and Chemotherapy, 1981, 19 1: 940-940. DOI: 10.1128/aac.19.5.940-b
[2] SIZHUANG YAN Dennis L S Paul M Mendelman. The in vitro antibacterial activity of ceftriaxone against Streptococcus pyogenes is unrelated to penicillin-binding protein 4[J]. Fems Microbiology Letters, 1993, 110 3: Pages 313-317.
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J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
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0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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