| Identification | Back Directory | [Name]
sabeluzole | [CAS]
104383-17-7 | [Synonyms]
1-Piperidineethanol, 4-(2-benzothiazolylmethylamino)-alpha-((4-fluorophenoxy)methyl)-, (+-)- | [Molecular Formula]
C22H26FN3O2S | [MOL File]
104383-17-7.mol | [Molecular Weight]
415.53 |
| Chemical Properties | Back Directory | [Melting point ]
101.7° | [Boiling point ]
577.4±60.0 °C(Predicted) | [density ]
1.288±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
15.06±0.20(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C22H26FN3O2S/c1-25(22-24-20-4-2-3-5-21(20)29-22)17-10-12-26(13-11-17)14-18(27)15-28-19-8-6-16(23)7-9-19/h2-9,17-18,27H,10-15H2,1H3 | [InChIKey]
IGMKTIJBFUMVIN-UHFFFAOYSA-N | [SMILES]
Fc1ccc(cc1)OCC(O)CN2CCC(CC2)N(C)c3[s]c4c(n3)cccc4 |
| Hazard Information | Back Directory | [Uses]
Anticonvulsant; antihypoxic. | [Definition]
ChEBI: Sabeluzole is a member of benzothiazoles. | [Biological Activity]
Sabeluzole is a benzothiazole derivative th at exerts neuroprotective and cognition-enhancing (nootropic) efficacy by preventing NMDA- and glutamate-induced neurotoxicity. | [in vivo]
Sabeluzole (5 mg/kg, 25 mg/kg; sc; twice dose with 72 h interval) shows positive and memory enhancing properties in habituation amnesia male rats induced with 20 mg/kg Chlordiazepoxide[2].
| Animal Model: | Adult albino male rats (270-330 g) induced by Chlordiazepoxide[2] | | Dosage: | 5 mg/kg, 25 mg/kg | | Administration: | SC; 0.5 ml/kg; twice dose with 72 h interval; 1 h before 20 mg/kg Chlordiazepoxide | | Result: | Showed the positive effects on several learning and memory tasks in rats.
Did not influence locomotor and rearing activity of animals during the acquisition session. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
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