Identification | Back Directory | [Name]
LL 3858 | [CAS]
1044503-04-9 | [Synonyms]
LL 3858 Sudoterb HCl LL-3858 dihydrchloride Sudoterb (hydrochloride (1:2)) N-[2-methyl-5-phenyl-3-[[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]pyrrol-1-yl]pyridine-4-carboxamide:dihydrochloride | [Molecular Formula]
C29H29ClF3N5O | [MDL Number]
MFCD18633306 | [MOL File]
1044503-04-9.mol | [Molecular Weight]
556.03 |
Hazard Information | Back Directory | [Uses]
Sudoterb (LL 3858) hydrochloride is an orally active anti-Tuberculosis agent[1]. | [in vivo]
Sudoterb hydrochloride (12.5 mg/kg and 25 mg/kg, p.o., 4 and 8 weeks) is effective against M.tuberculosis in mice[2].
Sudoterb hydrochloride (p.o., mice) shows a LD50 of 700 mg/kg[2].
| [References]
[1] Maha A. Elhakeem, et al. Synthesis and anti-mycobacterial evaluation of some new isonicotinylhydrazide analogues. Bulletin of Faculty of Pharmacy, Cairo University. 2015, 53 (1), 45-52 [2] Protopopova M, et al. In search of new cures for tuberculosis. Med Chem. 2007 May;3(3):301-16. DOI:10.2174/157340607780620626 |
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Company Name: |
SPIRO PHARMA
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Tel: |
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Website: |
www.spiropharma.com.cn |
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