| Identification | Back Directory | [Name]
L-talo-Non-2-enonicacid,5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]-2-oxiranyl]methyl]-3-methyl-,8-carboxyoctyl ester, calcium salt (2:1), (2E)- | [CAS]
104486-81-9 | [Synonyms]
L-talo-Non-2-enonicacid,5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]-2-oxiranyl]methyl]-3-methyl-,8-carboxyoctyl ester, calcium salt (2:1), (2E)- | [Molecular Formula]
C26H46CaO9 | [MDL Number]
MFCD31692655 | [MOL File]
104486-81-9.mol | [Molecular Weight]
542.72 |
| Hazard Information | Back Directory | [Uses]
Antibacterial (topical). | [Definition]
ChEBI: Mupirocin calcium (anhydrous) is the anhydrous form of the calcium salt of mupirocin. The dihydrate form is used as an antibacterial drug for the treatment of skin infections. It has a role as an antibacterial drug and a protein synthesis inhibitor. It contains a mupirocin(1-). | [Brand name]
Bactroban (GlaxoSmithKline). | [in vivo]
MRSA: Meticillin-resistant Staphylococcus aureus
Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].
Mupirocin calcium (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment[3].
Mupirocin calcium (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice[4].
Mupirocin calcium (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis[5]. | Animal Model: | MRSA skin infection model in mice (10-12 weeks old)[3] | | Dosage: | 2% ointment | | Administration: | External administration; twice daily; 3-6 days | | Result: | Reduced the total bacterial loads in the skin lesions, and decreased by 2.0, 5.1 log10 CFU on day 3 and 6, respectively.
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| Animal Model: | Diabetic pressure ulcer mouse model (33.2-39.2 g)[4] | | Dosage: | 2% ointment | | Administration: | External administration; 4 days | | Result: | Resulted less superficial mats of bacterial colonies, and improved histopathology evaluation.
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| Animal Model: | Adult male Wistar rats (weight 275-325 g)[5] | | Dosage: | Impregnated with 100 μg of mupirocin/mL; segments:1.5 cm *1 cm2 | | Administration: | Subcutaneous implantation; 7 days | | Result: | Resulted in preventing S. epidermidis infection of the graft in a rat model with spontaneously bound to collagen-sealed Dacron grafts.
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